ABSTRACT
Objective: To evaluate the association between lymphovascular invasion [LVI] and different clinicopathologic features of invasive breast cancer
Methods: Clinicopathologic and demographic data from a cohort of 298 patients, who were referred to surgery clinics at King Hussein Medical Center [KHMC] between 2007 and 2014, were retrieved and analyzed
Results: The average age of the cohort under investigation was 51.2 years with most of the patients having invasive breast carcinoma. Lymphovascular invasion was detected in 53% of the patients. Patients with lymphovascular invasion were more likely to have larger tumors [4.2 vs. 3.3cm p=0.02]. Additionally, they were more likely to have progesterone negative [p=0.032], and Her2 positive tumors [p=0.003]. Patients with negative Lymphovascular were more likely to have negative perineural invasion [p=0.0001]
Conclusion: Lymphovascular invasion was associated with larger tumors, Progesterone negativity and Her-2 positivity. Lymphovascular invasion should be incorporated in tumor classification and treatment modality selection